Overview
5-Amino-1MQ is a research-grade peptide compound that has attracted significant attention in the scientific community for its role in metabolic regulation. Selective NNMT inhibitor. Studied for activation of cellular energy expenditure and reduction of lipid accumulation in adipocyte models.
This compound belongs to the metabolic category of research peptides and has been the subject of numerous preclinical investigations. Its unique molecular properties make it a valuable tool for researchers exploring novel therapeutic pathways.
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme upregulated in adipose tissue during obesity. NNMT inhibition increases intracellular NAD+ and SAM concentrations, boosting cellular energy expenditure via sirtuin activation. In diet-induced obesity models, it reduced lipid accumulation without affecting lean tissue mass or food intake. The growing body of published literature continues to expand our understanding of this compound's potential applications in laboratory settings.
Mechanism of Action
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme upregulated in adipose tissue during obesity. NNMT inhibition increases intracellular NAD+ and SAM concentrations, boosting cellular energy expenditure via sirtuin activation. In diet-induced obesity models, it reduced lipid accumulation without affecting lean tissue mass or food intake.
The signaling pathways activated by 5-Amino-1MQ continue to be mapped through proteomic and transcriptomic analyses. Current research focuses on identifying the specific receptor subtypes and downstream effectors responsible for the observed biological responses. Understanding these molecular interactions is critical for advancing the compound from preclinical investigation toward potential translational applications.
Research Areas
- Metabolic pathway regulation research
- Glucose homeostasis and insulin sensitivity
- Energy expenditure and lipid metabolism
- Satiety signaling mechanisms
- Metabolic flux analysis
Compound Specifications
| CAS Number | 82575-32-8 |
| Purity | ≥99% HPLC verified |
| Storage | Room temperature, dry place. Protect from light. |
| Category | Metabolic |
| Price | €55 |
| Format | 50mg capsules (30ct) |
Available Formats
- 50mg × 30 capsules
- 50mg × 60 capsules
Dissolution
Use our dilution calculator for precise concentration calculations.