Overview
BAM15 is a research-grade peptide compound that has attracted significant attention in the scientific community for its role in metabolic regulation. Selective mitochondrial protonophore. Studied for uncoupling oxidative phosphorylation to increase energy expenditure without raising core body temperature.
This compound belongs to the metabolic category of research peptides and has been the subject of numerous preclinical investigations. Its unique molecular properties make it a valuable tool for researchers exploring novel therapeutic pathways.
BAM15 is a mitochondria-selective protonophore that dissipates the proton gradient across the inner mitochondrial membrane, uncoupling electron transport from ATP synthesis. Unlike classical uncouplers (DNP), BAM15 does not depolarize the plasma membrane, avoiding off-target toxicity. In rodent models, it increased fatty acid oxidation, reduced lipid accumulation, improved insulin sensitivity, and decreased hepatic lipid storage — all without hyperthermia or reduced food intake. The growing body of published literature continues to expand our understanding of this compound's potential applications in laboratory settings.
Mechanism of Action
BAM15 is a mitochondria-selective protonophore that dissipates the proton gradient across the inner mitochondrial membrane, uncoupling electron transport from ATP synthesis. Unlike classical uncouplers (DNP), BAM15 does not depolarize the plasma membrane, avoiding off-target toxicity. In rodent models, it increased fatty acid oxidation, reduced lipid accumulation, improved insulin sensitivity, and decreased hepatic lipid storage — all without hyperthermia or reduced food intake.
The signaling pathways activated by BAM15 continue to be mapped through proteomic and transcriptomic analyses. Current research focuses on identifying the specific receptor subtypes and downstream effectors responsible for the observed biological responses. Understanding these molecular interactions is critical for advancing the compound from preclinical investigation toward potential translational applications.
Research Areas
- Metabolic pathway regulation research
- Glucose homeostasis and insulin sensitivity
- Energy expenditure and lipid metabolism
- Satiety signaling mechanisms
- Metabolic flux analysis
Compound Specifications
| CAS Number | 210538-09-5 |
| Purity | ≥99% HPLC verified |
| Storage | −20 °C, dry, protect from light. |
| Category | Metabolic |
| Price | €48 |
| Format | 50mg powder |
Available Formats
- 25mg vial
- 50mg vial
Dissolution
Use our dilution calculator for precise concentration calculations.