Overview
Gonadorelin is a research-grade peptide compound that has attracted significant attention in the scientific community for its role in bioactive optimization. Synthetic GnRH decapeptide. Studied for pulsatile stimulation of LH and FSH release from the anterior pituitary.
This compound belongs to the bioactive category of research peptides and has been the subject of numerous preclinical investigations. Its unique molecular properties make it a valuable tool for researchers exploring novel therapeutic pathways.
Gonadorelin (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂) is identical to endogenous gonadotropin-releasing hormone. It binds GnRH receptors on anterior pituitary gonadotropes, triggering release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Pulsatile administration maintains hypothalamic-pituitary-gonadal axis function, while continuous exposure leads to receptor desensitization. The growing body of published literature continues to expand our understanding of this compound's potential applications in laboratory settings.
Mechanism of Action
Gonadorelin (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂) is identical to endogenous gonadotropin-releasing hormone. It binds GnRH receptors on anterior pituitary gonadotropes, triggering release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Pulsatile administration maintains hypothalamic-pituitary-gonadal axis function, while continuous exposure leads to receptor desensitization.
The signaling pathways activated by Gonadorelin continue to be mapped through proteomic and transcriptomic analyses. Current research focuses on identifying the specific receptor subtypes and downstream effectors responsible for the observed biological responses. Understanding these molecular interactions is critical for advancing the compound from preclinical investigation toward potential translational applications.
Research Areas
- Growth hormone secretion pathway analysis
- Neurotrophic factor expression research
- Receptor binding kinetics
- Hormonal axis modulation
- Signal transduction research
Compound Specifications
| CAS Number | 33515-09-2 |
| Purity | ≥99% HPLC-MS verified |
| Storage | −20 °C lyophilised. 2–8 °C after dissolution, ≤14 days. |
| Category | Bioactive |
| Price | €35 |
| Format | 2mg lyophilised |
Available Formats
- 2mg vial
Dissolution
Use our dilution calculator for precise concentration calculations.