Overview
SS-31 (Elamipretide) is a research-grade peptide compound that has attracted significant attention in the scientific community for its role in cellular and anti-aging. Mitochondria-targeted tetrapeptide. Studied for restoration of bioenergetic function, reduction of oxidative stress, and cellular rejuvenation.
This compound belongs to the cellular category of research peptides and has been the subject of numerous preclinical investigations. Its unique molecular properties make it a valuable tool for researchers exploring novel therapeutic pathways.
SS-31 (D-Arg-Dmt-Lys-Phe-NH₂) selectively concentrates in the inner mitochondrial membrane by binding to cardiolipin. This interaction optimizes electron transport chain efficiency, reduces electron leak and ROS generation, and stabilizes cytochrome c interactions. Studies demonstrate restoration of ATP production and protection against ischemia-reperfusion injury in cardiac and renal tissue models. The growing body of published literature continues to expand our understanding of this compound's potential applications in laboratory settings.
Mechanism of Action
SS-31 (D-Arg-Dmt-Lys-Phe-NH₂) selectively concentrates in the inner mitochondrial membrane by binding to cardiolipin. This interaction optimizes electron transport chain efficiency, reduces electron leak and ROS generation, and stabilizes cytochrome c interactions. Studies demonstrate restoration of ATP production and protection against ischemia-reperfusion injury in cardiac and renal tissue models.
The signaling pathways activated by SS-31 (Elamipretide) continue to be mapped through proteomic and transcriptomic analyses. Current research focuses on identifying the specific receptor subtypes and downstream effectors responsible for the observed biological responses. Understanding these molecular interactions is critical for advancing the compound from preclinical investigation toward potential translational applications.
Research Areas
- Telomere biology and cellular aging
- Mitochondrial function optimization
- Oxidative stress resistance
- Circadian rhythm regulation
- Cellular senescence pathways
Compound Specifications
| CAS Number | 736992-21-5 |
| Purity | ≥98% HPLC-MS verified |
| Storage | −20 °C lyophilised. 2–8 °C after dissolution, ≤7 days. |
| Category | Cellular Maintenance |
| Price | €72 |
| Format | 5mg lyophilised |
Available Formats
- 1mg vial
- 5mg vial
Dissolution
Use our dilution calculator for precise concentration calculations.