Overview
Humanin is a research-grade peptide compound that has attracted significant attention in the scientific community for its role in cellular and anti-aging. Mitochondria-encoded micropeptide. Studied alongside MOTS-c for cytoprotective, anti-apoptotic, and metabolic signaling properties.
This compound belongs to the cellular category of research peptides and has been the subject of numerous preclinical investigations. Its unique molecular properties make it a valuable tool for researchers exploring novel therapeutic pathways.
Humanin is a 24-amino-acid peptide encoded by mitochondrial DNA (MT-RNR2). It binds the trimeric receptor complex (CNTFR/WSX-1/gp130) and activates STAT3 signaling, promoting cell survival. It also binds IGFBP-3 and Bax, inhibiting intrinsic apoptosis. The S14G analog (HNG) shows enhanced potency. Studied in models of neurodegeneration, ischemia, and metabolic dysfunction. The growing body of published literature continues to expand our understanding of this compound's potential applications in laboratory settings.
Mechanism of Action
Humanin is a 24-amino-acid peptide encoded by mitochondrial DNA (MT-RNR2). It binds the trimeric receptor complex (CNTFR/WSX-1/gp130) and activates STAT3 signaling, promoting cell survival. It also binds IGFBP-3 and Bax, inhibiting intrinsic apoptosis. The S14G analog (HNG) shows enhanced potency. Studied in models of neurodegeneration, ischemia, and metabolic dysfunction.
The signaling pathways activated by Humanin continue to be mapped through proteomic and transcriptomic analyses. Current research focuses on identifying the specific receptor subtypes and downstream effectors responsible for the observed biological responses. Understanding these molecular interactions is critical for advancing the compound from preclinical investigation toward potential translational applications.
Research Areas
- Telomere biology and cellular aging
- Mitochondrial function optimization
- Oxidative stress resistance
- Circadian rhythm regulation
- Cellular senescence pathways
Compound Specifications
| CAS Number | 330936-69-1 |
| Purity | ≥95% HPLC verified |
| Storage | −20 °C lyophilised. Avoid repeated freeze-thaw cycles. |
| Category | Cellular Maintenance |
| Price | €78 |
| Format | 5mg lyophilised |
Available Formats
- 1mg vial
- 5mg vial
Dissolution
Use our dilution calculator for precise concentration calculations.