Overview
KPV is a research-grade peptide compound that has attracted significant attention in the scientific community for its role in tissue reagent and repair. C-terminal tripeptide of alpha-MSH. Studied for potent anti-inflammatory activity in gut and skin tissue models.
This compound belongs to the reagent category of research peptides and has been the subject of numerous preclinical investigations. Its unique molecular properties make it a valuable tool for researchers exploring novel therapeutic pathways.
KPV (Lys-Pro-Val) is derived from the C-terminus of alpha-melanocyte-stimulating hormone. It inhibits NF-κB activation and reduces pro-inflammatory cytokine production (TNF-α, IL-6, IL-1β) in cellular models. Studies show activity in gut epithelial and dermal fibroblast assays without melanocortin receptor-mediated pigmentation effects. The growing body of published literature continues to expand our understanding of this compound's potential applications in laboratory settings.
Mechanism of Action
KPV (Lys-Pro-Val) is derived from the C-terminus of alpha-melanocyte-stimulating hormone. It inhibits NF-κB activation and reduces pro-inflammatory cytokine production (TNF-α, IL-6, IL-1β) in cellular models. Studies show activity in gut epithelial and dermal fibroblast assays without melanocortin receptor-mediated pigmentation effects.
The signaling pathways activated by KPV continue to be mapped through proteomic and transcriptomic analyses. Current research focuses on identifying the specific receptor subtypes and downstream effectors responsible for the observed biological responses. Understanding these molecular interactions is critical for advancing the compound from preclinical investigation toward potential translational applications.
Research Areas
- Extracellular matrix remodeling dynamics
- Anti-inflammatory pathway modulation
- Connective tissue signal transduction
- Collagen synthesis pathway investigation
- Cytoprotective mechanism analysis
Compound Specifications
| CAS Number | 67727-97-3 |
| Purity | ≥98% HPLC verified |
| Storage | −20 °C lyophilised. 2–8 °C after dissolution, ≤14 days. |
| Category | Tissue Remodeling |
| Price | €45 |
| Format | 10mg lyophilised |
Available Formats
- 5mg vial
- 10mg vial
Dissolution
Use our dilution calculator for precise concentration calculations.