Overview
LL-37 is a research-grade peptide compound that has attracted significant attention in the scientific community for its role in tissue reagent and repair. Human cathelicidin antimicrobial peptide. Studied for broad-spectrum antimicrobial, immunomodulatory, and tissue remodeling properties.
This compound belongs to the reagent category of research peptides and has been the subject of numerous preclinical investigations. Its unique molecular properties make it a valuable tool for researchers exploring novel therapeutic pathways.
LL-37 is the only human cathelicidin-derived antimicrobial peptide. It disrupts microbial membranes through electrostatic interactions with negatively charged lipid bilayers. Beyond direct antimicrobial activity, it modulates innate immunity by promoting chemotaxis of immune cells, neutralizing endotoxins (LPS), and enhancing tissue remodeling through keratinocyte and fibroblast migration. The growing body of published literature continues to expand our understanding of this compound's potential applications in laboratory settings.
Mechanism of Action
LL-37 is the only human cathelicidin-derived antimicrobial peptide. It disrupts microbial membranes through electrostatic interactions with negatively charged lipid bilayers. Beyond direct antimicrobial activity, it modulates innate immunity by promoting chemotaxis of immune cells, neutralizing endotoxins (LPS), and enhancing tissue remodeling through keratinocyte and fibroblast migration.
The signaling pathways activated by LL-37 continue to be mapped through proteomic and transcriptomic analyses. Current research focuses on identifying the specific receptor subtypes and downstream effectors responsible for the observed biological responses. Understanding these molecular interactions is critical for advancing the compound from preclinical investigation toward potential translational applications.
Research Areas
- Extracellular matrix remodeling dynamics
- Anti-inflammatory pathway modulation
- Connective tissue signal transduction
- Collagen synthesis pathway investigation
- Cytoprotective mechanism analysis
Compound Specifications
| CAS Number | 154947-66-7 |
| Purity | ≥95% HPLC verified |
| Storage | −20 °C lyophilised. Avoid repeated freeze-thaw. |
| Category | Tissue Remodeling |
| Price | €58 |
| Format | 5mg lyophilised |
Available Formats
- 1mg vial
- 5mg vial
Dissolution
Use our dilution calculator for precise concentration calculations.